Host defense during Klebsiella pneumonia relies on hematopoietic expressed TLR4 and TLR2
نویسندگان
چکیده
Catharina W. Wieland* , , , Miriam H. P. van Lieshout* , Arie J. Hoogendijk* and Tom van der Poll* *Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Center of Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
منابع مشابه
Host defence during Klebsiella pneumonia relies on haematopoietic-expressed Toll-like receptors 4 and 2.
In this study, the relative roles of Toll-like receptor (TLR)2 and TLR4 were investigated independently and together. Moreover, we studied the role of haematopoietic compartment in anti-Klebsiella host defence. We infected TLR2 and TLR4 single-, and TLR2×4 double knockout (KO) animals with different doses of Klebsiella pneumoniae. In addition, bone marrow chimeric mice were created and infected...
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